Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A(2B) Adenosine Receptor Antagonists

[Image: see text] We describe the discovery and optimization of 3,4-dihydropyrimidin-2(1H)-ones as a novel family of (nonxanthine) A(2B) receptor antagonists that exhibit an unusually high selectivity profile. The Biginelli-based hit optimization process enabled a thoughtful exploration of the struc...

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Библиографические подробности
Главные авторы: Crespo, Abel, El Maatougui, Abdelaziz, Biagini, Pierfrancesco, Azuaje, Jhonny, Coelho, Alberto, Brea, José, Loza, María Isabel, Cadavid, María Isabel, García-Mera, Xerardo, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2013
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027370/
https://ncbi.nlm.nih.gov/pubmed/24900602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400185v
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