Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis

Recent studies report the involvement of intra-ovarian factors, such as inflammation and oxidative stress, in the pathophysiology of polycystic ovary syndrome (PCOS), the most common endocrine disorder of reproductive age women. Endoplasmic reticulum (ER) stress is a local factor that affects variou...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Takahashi, Nozomi, Harada, Miyuki, Hirota, Yasushi, Nose, Emi, Azhary, Jerilee MK, Koike, Hiroshi, Kunitomi, Chisato, Yoshino, Osamu, Izumi, Gentaro, Hirata, Tetsuya, Koga, Kaori, Wada-Hiraike, Osamu, Chang, R. Jeffrey, Shimasaki, Shunichi, Fujii, Tomoyuki, Osuga, Yutaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589802/
https://ncbi.nlm.nih.gov/pubmed/28883502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11252-7
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