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SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms

Suppressors of cytokine signaling (SOCS) proteins inhibit signaling by serving as substrate receptors for the Cullin5-RING E3 ubiquitin ligase (CRL5) and through a variety of CRL5-independent mechanisms. CRL5, SOCS2 and SOCS6 are implicated in suppressing transformation of epithelial cells. We ident...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pilling, Carissa, Cooper, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589800/
https://ncbi.nlm.nih.gov/pubmed/28883622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11040-3
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