New compounds identified through in silico approaches reduce the α-synuclein expression by inhibiting prolyl oligopeptidase in vitro

Prolyl oligopeptidase (POP) is a serine protease that is responsible for the maturation and degradation of short neuropeptides and peptide hormones. The inhibition of POP has been demonstrated in the treatment of α-synucleinopathies and several neurological conditions. Therefore, ligand-based and st...

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Vydáno v:Sci Rep
Hlavní autoři: Kumar, Raj, Bavi, Rohit, Jo, Min Gi, Arulalapperumal, Venkatesh, Baek, Ayoung, Rampogu, Shailima, Kim, Myeong Ok, Lee, Keun Woo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589771/
https://ncbi.nlm.nih.gov/pubmed/28883518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11302-0
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