Washing in hypotonic saline reduces the fraction of irreversibly-damaged cells in stored blood: a proof-of-concept study

BACKGROUND: During hypothermic storage, a substantial fraction of red blood cells (RBCs) transforms from flexible discocytes to rigid sphero-echinocytes and spherocytes. Infusion of these irreversibly-damaged cells into the recipient during transfusion serves no therapeutic purpose and may contribut...

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Veröffentlicht in:Blood Transfus
Hauptverfasser: Xia, Hui, Khanal, Grishma, Strachan, Briony C., Vörös, Eszter, Piety, Nathaniel Z., Gifford, Sean C., Shevkoplyas, Sergey S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Edizioni SIMTI - SIMTI Servizi Srl 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589709/
https://ncbi.nlm.nih.gov/pubmed/28686152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2450/2017.0013-17
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