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Improved expansion of T-cells in culture when isolated with an equipment-free, high-throughput, flow-through microfluidic module versus traditional density gradient centrifugation

BACKGROUND: The isolation of lymphocytes – and removal of platelets (PLTs) and red blood cells (RBCs) – from an initial blood sample prior to culture is a key enabling step for effective manufacture of cellular therapies. Unfortunately, currently-available methods suffer from various drawbacks – inc...

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Detalhes bibliográficos
Publicado no:Cytotherapy
Main Authors: Strachan, Briony C., Xia, Hui, Vörös, Eszter, Gifford, Sean C., Shevkoplyas, Sergey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435405/
https://ncbi.nlm.nih.gov/pubmed/30660490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2018.12.004
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