Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity

Platinum-based chemotherapeutics are amongst the most powerful anti-cancer drugs. Although their exact mechanism of action is not well understood, it is thought to be mediated through covalent DNA binding. We investigated the effect of platinum-based chemotherapeutics on signaling through signal tra...

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書誌詳細
出版年:Oncotarget
主要な著者: Hato, Stanleyson V., Figdor, Carl G., Takahashi, Susumu, Pen, Anja E., Halilovic, Altuna, Bol, Kalijn F., Vasaturo, Angela, Inoue, Yukie, de Haas, Nienke, Verweij, Dagmar, Van Herpen, Carla M.L., Kaanders, Johannes H., van Krieken, Johan H.J.M., Van Laarhoven, Hanneke W.M., Hooijer, Gerrit K.J., Punt, Cornelis J.A., Asai, Akira, de Vries, I. Jolanda M., Lesterhuis, W.J.
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2017
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589592/
https://ncbi.nlm.nih.gov/pubmed/28903353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17661
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