Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity

Platinum-based chemotherapeutics are amongst the most powerful anti-cancer drugs. Although their exact mechanism of action is not well understood, it is thought to be mediated through covalent DNA binding. We investigated the effect of platinum-based chemotherapeutics on signaling through signal tra...

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Publicat a:Oncotarget
Autors principals: Hato, Stanleyson V., Figdor, Carl G., Takahashi, Susumu, Pen, Anja E., Halilovic, Altuna, Bol, Kalijn F., Vasaturo, Angela, Inoue, Yukie, de Haas, Nienke, Verweij, Dagmar, Van Herpen, Carla M.L., Kaanders, Johannes H., van Krieken, Johan H.J.M., Van Laarhoven, Hanneke W.M., Hooijer, Gerrit K.J., Punt, Cornelis J.A., Asai, Akira, de Vries, I. Jolanda M., Lesterhuis, W.J.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589592/
https://ncbi.nlm.nih.gov/pubmed/28903353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17661
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