Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

Tumor microenvironments feature immune inhibitory mechanisms that prevent T cells from generating effective antitumor immune responses. Therapeutic interventions aimed at disrupting these inhibitory mechanisms have been shown to enhance antitumor immunity, but they lack direct cytotoxic effects. Her...

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Detalhes bibliográficos
Main Authors: Lesterhuis, W. Joost, Punt, Cornelis J.A., Hato, Stanleyson V., Eleveld-Trancikova, Dagmar, Jansen, Bastiaan J.H., Nierkens, Stefan, Schreibelt, Gerty, de Boer, Annemiek, Van Herpen, Carla M.L., Kaanders, Johannes H., van Krieken, Johan H.J.M., Adema, Gosse J., Figdor, Carl G., de Vries, I. Jolanda M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148725/
https://ncbi.nlm.nih.gov/pubmed/21765211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43656
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