Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

Tumor microenvironments feature immune inhibitory mechanisms that prevent T cells from generating effective antitumor immune responses. Therapeutic interventions aimed at disrupting these inhibitory mechanisms have been shown to enhance antitumor immunity, but they lack direct cytotoxic effects. Her...

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書誌詳細
主要な著者: Lesterhuis, W. Joost, Punt, Cornelis J.A., Hato, Stanleyson V., Eleveld-Trancikova, Dagmar, Jansen, Bastiaan J.H., Nierkens, Stefan, Schreibelt, Gerty, de Boer, Annemiek, Van Herpen, Carla M.L., Kaanders, Johannes H., van Krieken, Johan H.J.M., Adema, Gosse J., Figdor, Carl G., de Vries, I. Jolanda M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2011
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148725/
https://ncbi.nlm.nih.gov/pubmed/21765211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43656
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