Functional differences between PD-1(+) and PD-1(-) CD4(+) effector T cells in healthy donors and patients with glioblastoma multiforme

Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) have been highly successful in the treatment of cancer. While PD-1 expression has been widely investigated, its role in CD4(+) effector T cells in the setting of health and cancer remains unclear, particularly in the setti...

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Udgivet i:PLoS One
Main Authors: Goods, Brittany A., Hernandez, Amanda L., Lowther, Daniel E., Lucca, Liliana E., Lerner, Benjamin A., Gunel, Murat, Raddassi, Khadir, Coric, Vlad, Hafler, David A., Love, J. Christopher
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589094/
https://ncbi.nlm.nih.gov/pubmed/28880903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181538
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