PD-1 marks dysfunctional regulatory T cells in malignant gliomas

Immunotherapies targeting the immune checkpoint receptor programmed cell death protein 1 (PD-1) have shown remarkable efficacy in treating cancer. CD4(+)CD25(hi)FoxP3(+) Tregs are critical regulators of immune responses in autoimmunity and malignancies, but the functional status of human Tregs expre...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Lowther, Daniel E., Goods, Brittany A., Lucca, Liliana E., Lerner, Benjamin A., Raddassi, Khadir, van Dijk, David, Hernandez, Amanda L., Duan, Xiangguo, Gunel, Murat, Coric, Vlad, Krishnaswamy, Smita, Love, J. Christopher, Hafler, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864991/
https://ncbi.nlm.nih.gov/pubmed/27182555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85935
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