Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40

Anti-tumor efficacy of T cells engineered to express chimeric antigen receptors (CARs) is dependent on their specificity, survival, and in vivo expansion following adoptive transfer. Toll-like receptor (TLR) and CD40 signaling in T cells can improve persistence and drive proliferation of antigen-spe...

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Vydáno v:Mol Ther
Hlavní autoři: Foster, Aaron E., Mahendravada, Aruna, Shinners, Nicholas P., Chang, Wei-Chun, Crisostomo, Jeannette, Lu, An, Khalil, Mariam, Morschl, Eva, Shaw, Joanne L., Saha, Sunandan, Duong, MyLinh T., Collinson-Pautz, Matthew R., Torres, David L., Rodriguez, Tania, Pentcheva-Hoang, Tsvetelina, Bayle, J. Henri, Slawin, Kevin M., Spencer, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589084/
https://ncbi.nlm.nih.gov/pubmed/28697888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.06.014
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