Phase I Trial of Aflibercept (VEGF Trap) with Radiation Therapy and Concomitant and Adjuvant Temozolomide in Patients with High-Grade Gliomas

BACKGROUND: Anti-vascular endothelial growth factor (VEGF) therapy has shown promise in the treatment of high-grade gliomas (HGG). Aflibercept is a recombinant human fusion protein that acts as a soluble decoy receptor for VEGF-A, VEGF-B and placental growth factor (PlGF), depleting circulating leve...

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Detalhes bibliográficos
Publicado no:J Neurooncol
Main Authors: Nayak, Lakshmi, de Groot, John, Wefel, Jeffrey S, Cloughesy, Timothy F, Lieberman, Frank, Chang, Susan M, Omuro, Antonio, Drappatz, Jan, Batchelor, Tracy T, DeAngelis, Lisa M, Gilbert, Mark R, Aldape, Kenneth D, Yung, Alfred WK, Fisher, Joy, Ye, Xiaobu, Chen, Alice, Grossman, Stuart, Prados, Michael, Wen, Patrick Y
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588922/
https://ncbi.nlm.nih.gov/pubmed/28116649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-016-2357-9
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