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Threshold effect of G9a/Glp on peripheral nerve injury-induced hypersensitivity

BACKGROUND: Previous studies disclosed the pivotal role of methyltransferase complex G9a/Glp in the pathogenesis of neuropathic hypersensitivity induced by peripheral nerve injury. We observed that higher dose of G9a inhibitor improved nociceptive behavior, but the lower dose worsened pain. The aim...

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Detalhes bibliográficos
Publicado no:Mol Pain
Main Authors: Wang, Xian, Shen, Xiaofeng, Ma, Shaolei, Liu, Yusheng, Xu, Shiqin, Wu, Shizheng, Wang, Fuzhou
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588794/
https://ncbi.nlm.nih.gov/pubmed/28814147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806917729305
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