Characterization of the redox transition of the XRCC1 N-terminal domain

XRCC1, a scaffold protein involved in DNA repair, contains an N-terminal domain (X1NTD) that interacts specifically with DNA polymerase β. It was recently discovered that X1NTD contains a disulfide switch that allows it to adopt either of two metamorphic structures. In the present study we demonstra...

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Publicado en:Structure
Autores principales: Gabel, Scott A., Smith, Cassandra E., Cuneo, Matthew J., Mueller, Geoffrey A., Kirby, Thomas W., DeRose, Eugene F., Krahn, Juno M., London, Robert E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588702/
https://ncbi.nlm.nih.gov/pubmed/25456813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.09.012
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