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Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase β binding affinity

Formation of a complex between the XRCC1 N-terminal domain (NTD) and DNA polymerase β (Pol β) is central to base excision repair of damaged DNA. Two crystal forms of XRCC1-NTD complexed with Pol β have been solved, revealing that the XRCC1-NTD is able to adopt a redox-dependent alternate fold, chara...

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Détails bibliographiques
Auteurs principaux: Cuneo, Matthew J., London, Robert E.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872404/
https://ncbi.nlm.nih.gov/pubmed/20351257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914077107
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