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Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase β binding affinity
Formation of a complex between the XRCC1 N-terminal domain (NTD) and DNA polymerase β (Pol β) is central to base excision repair of damaged DNA. Two crystal forms of XRCC1-NTD complexed with Pol β have been solved, revealing that the XRCC1-NTD is able to adopt a redox-dependent alternate fold, chara...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2872404/ https://ncbi.nlm.nih.gov/pubmed/20351257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914077107 |
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