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5FU resistance caused by reduced fluoro-deoxyuridine monophosphate and its reversal using deoxyuridine
The mechanism of 5-fluorouracil (5FU) resistance was investigated, focusing on the level of thymidylate synthase (TS) ternary complex formed with fluoro-deoxyuridine monophosphate (FdUMP). MKN45 and 5FU-resistant MKN45/F2R cells were treated with 5FU and fluoro-deoxyuridine (FdU) in combination with...
Gardado en:
| Publicado en: | Oncol Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
D.A. Spandidos
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5588021/ https://ncbi.nlm.nih.gov/pubmed/28927061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.6512 |
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