Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation

The cell penetrating peptide, Pep-1, has been shown to facilitate cellular uptake of foreign mitochondria but further research is required to evaluate the use of Pep-1-mediated mitochondrial delivery (PMD) in treating mitochondrial defects. Presently, we sought to determine whether mitochondrial tra...

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Vydáno v:Sci Rep
Hlavní autoři: Chang, Jui-Chih, Hoel, Fredrik, Liu, Ko-Hung, Wei, Yau-Huei, Cheng, Fu-Chou, Kuo, Shou-Jen, Tronstad, Karl Johan, Liu, Chin-San
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587702/
https://ncbi.nlm.nih.gov/pubmed/28878349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10870-5
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