Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

BACKGROUND: Merkel cell carcinoma is a rare, aggressive skin cancer with poor prognosis in patients with advanced disease. Current standard care uses various cytotoxic chemotherapy regimens, but responses are seldom durable. Tumour oncogenesis is linked to Merkel cell polyomavirus integration and ul...

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Detalhes bibliográficos
Publicado no:Lancet Oncol
Main Authors: Kaufman, Howard L, Russell, Jeffery, Hamid, Omid, Bhatia, Shailender, Terheyden, Patrick, D’Angelo, Sandra P, Shih, Kent C, Lebbé, Céleste, Linette, Gerald P, Milella, Michele, Brownell, Isaac, Lewis, Karl D, Lorch, Jochen H, Chin, Kevin, Mahnke, Lisa, von Heydebreck, Anja, Cuillerot, Jean-Marie, Nghiem, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587154/
https://ncbi.nlm.nih.gov/pubmed/27592805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(16)30364-3
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