Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

BACKGROUND: Merkel cell carcinoma is a rare, aggressive skin cancer with poor prognosis in patients with advanced disease. Current standard care uses various cytotoxic chemotherapy regimens, but responses are seldom durable. Tumour oncogenesis is linked to Merkel cell polyomavirus integration and ul...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Lancet Oncol
Prif Awduron: Kaufman, Howard L, Russell, Jeffery, Hamid, Omid, Bhatia, Shailender, Terheyden, Patrick, D’Angelo, Sandra P, Shih, Kent C, Lebbé, Céleste, Linette, Gerald P, Milella, Michele, Brownell, Isaac, Lewis, Karl D, Lorch, Jochen H, Chin, Kevin, Mahnke, Lisa, von Heydebreck, Anja, Cuillerot, Jean-Marie, Nghiem, Paul
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587154/
https://ncbi.nlm.nih.gov/pubmed/27592805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(16)30364-3
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