Curvature and Rho activation differentially control the alignment of cells and stress fibers

In vivo, cells respond to a host of physical cues ranging from substrate stiffness to the organization of micro- and nanoscale fibrous networks. We show that macroscale substrates with radii of curvature from tens to hundreds of micrometers influence cell alignment. In a model system of fibroblasts,...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Bade, Nathan D., Kamien, Randall D., Assoian, Richard K., Stebe, Kathleen J.
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2017
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587136/
https://ncbi.nlm.nih.gov/pubmed/28913421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1700150
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