Fetal Exposure to High Maternal Thyroid Hormone Levels Causes Central Resistance to Thyroid Hormone in Adult Humans and Mice

CONTEXT: Fetuses exposed to the high thyroid hormone (TH) levels of mothers with resistance to thyroid hormone beta (RTH-β), due to mutations in the THRB gene, have low birth weight and suppressed TSH. OBJECTIVE: Determine if such exposure to high TH levels in embryonic life has a long-term effect i...

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Udgivet i:J Clin Endocrinol Metab
Main Authors: Srichomkwun, Panudda, Anselmo, João, Liao, Xiao-Hui, Hönes, G. Sebastian, Moeller, Lars C., Alonso-Sampedro, Manuela, Weiss, Roy E., Dumitrescu, Alexandra M., Refetoff, Samuel
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2017
Fag:
Clinical Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587072/
https://ncbi.nlm.nih.gov/pubmed/28586435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-00019
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