OR10-5 Reduced Sensitivity to Thyroid Hormone Due to Fetal Exposure to High Thyroid Hormone Levels Is Transmitted along Male Line to Two Subsequent Generations

Exposure of human embryos to high maternal thyroid hormone (TH) concentrations not only affects the newborn but also reduces thyrotroph sensitivity to TH during adult life. Based on results in mice, this latter effect is likely due to induction of the pituitary deiodinase type 3, which accelerates T...

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Vydáno v:J Endocr Soc
Hlavní autoři: Anselmo, Joao, Scherberg, Neal, Dumitrescu, Alexandra, Refetoff, Samuel
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2019
Témata:
Thyroid
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554845/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR10-5
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