AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome

CONTEXT: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk. Androgen excess is a defining feature of PCOS and has been suggested as causally associated with insuli...

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Detalles Bibliográficos
Publicado en:J Clin Endocrinol Metab
Autores principales: O’Reilly, Michael W., Kempegowda, Punith, Walsh, Mark, Taylor, Angela E., Manolopoulos, Konstantinos N., Allwood, J. William, Semple, Robert K., Hebenstreit, Daniel, Dunn, Warwick B., Tomlinson, Jeremy W., Arlt, Wiebke
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2017
Materias:
Clinical Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587066/
https://ncbi.nlm.nih.gov/pubmed/28645211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-00947
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