Histone Deacetylase 1 Depletion Activates Human Cardiac Mesenchymal Stromal Cell Proangiogenic Paracrine Signaling Through a Mechanism Requiring Enhanced Basic Fibroblast Growth Factor Synthesis and Secretion

BACKGROUND: Cardiac mesenchymal cell (CMC) administration improves cardiac function in animal models of heart failure. Although the precise mechanisms remain unclear, transdifferentiation and paracrine signaling are suggested to underlie their cardiac reparative effects. We have shown that histone d...

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Dettagli Bibliografici
Pubblicato in:J Am Heart Assoc
Autori principali: Moore, Joseph B., Zhao, John, Fischer, Annalara G., Keith, Matthew C.L., Hagan, David, Wysoczynski, Marcin, Bolli, Roberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586316/
https://ncbi.nlm.nih.gov/pubmed/28679560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.006183
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