Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck–Suzuki reaction

The synthesis of a previously undescribed sp(3)-rich 6-5-5-6 tetracyclic ring scaffold using a palladium catalysed domino Heck–Suzuki reaction is reported. This reaction is high-yielding, selective for the domino process over the direct Suzuki reaction and tolerant towards a variety of boronic acids...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Alza, Esther, Laraia, Luca, Ibbeson, Brett M., Collins, Súil, Galloway, Warren R. J. D., Stokes, Jamie E., Venkitaraman, Ashok R., Spring, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586250/
https://ncbi.nlm.nih.gov/pubmed/28966765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc02547d
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