In vitro repair of complex unligatable oxidatively induced DNA double-strand breaks by human cell extracts

We describe a new assay for in vitro repair of oxidatively induced DNA double-strand breaks (DSBs) by HeLa cell nuclear extracts. The assay employs linear plasmid DNA containing DNA DSBs produced by the radiomimetic drug bleomycin. The bleomycin-induced DSB possesses a complex structure similar to t...

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Dettagli Bibliografici

Pubblicato in:	Nucleic Acids Res
Autori principali:	Pastwa, Elzbieta, Neumann, Ronald D., Winters, Thomas A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2001
Soggetti:	NAR Methods Online
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55862/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11504886/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.16.e78
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