Efficacy of EZH2 inhibitory drugs in human papillomavirus-positive and human papillomavirus-negative oropharyngeal squamous cell carcinomas

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with rates of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase responsible f...

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Pubblicato in:Clin Epigenetics
Autori principali: Lindsay, Cameron D., Kostiuk, Morris A., Harris, Jeff, O’Connell, Daniel A., Seikaly, Hadi, Biron, Vincent L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586065/
https://ncbi.nlm.nih.gov/pubmed/28878842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0390-y
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