SRSF1 suppresses selection of intron-distal 5′ splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein

Dok-7 is a non-catalytic adaptor protein that facilitates agrin-induced clustering of acetylcholine receptors (AChR) at the neuromuscular junction. Alternative selection of 5′ splice sites (SSs) of DOK7 intron 4 generates canonical and frame-shifted transcripts. We found that the canonical full-leng...

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Published in:Sci Rep
Main Authors: Ahsan, Khalid Bin, Masuda, Akio, Rahman, Mohammad Alinoor, Takeda, Jun-ichi, Nazim, Mohammad, Ohkawara, Bisei, Ito, Mikako, Ohno, Kinji
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585400/
https://ncbi.nlm.nih.gov/pubmed/28874828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11036-z
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