Role of Smad3 and p38 Signalling in Cigarette Smoke-induced CFTR and BK dysfunction in Primary Human Bronchial Airway Epithelial Cells

Mucociliary clearance (MCC) is a major airway host defence system that is impaired in patients with smoking-associated chronic bronchitis. This dysfunction is partially related to a decrease of airway surface liquid (ASL) volume that is in part regulated by apically expressed cystic fibrosis transme...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Sailland, Juliette, Grosche, Astrid, Baumlin, Nathalie, Dennis, John S., Schmid, Andreas, Krick, Stefanie, Salathe, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585359/
https://ncbi.nlm.nih.gov/pubmed/28874823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11038-x
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