eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology

Neuronal physiology requires activity-driven protein translation, a process in which translation initiation factors are key players. We focus on eukaryotic initiation factor 4B (eIF4B), a regulator of protein translation, whose function in neurons is undetermined. We show that neuronal activity affe...

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Pubblicato in:Sci Rep
Autori principali: Bettegazzi, Barbara, Bellani, Serena, Roncon, Paolo, Guarnieri, Fabrizia Claudia, Bertero, Alice, Codazzi, Franca, Valtorta, Flavia, Simonato, Michele, Grohovaz, Fabio, Zacchetti, Daniele
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585320/
https://ncbi.nlm.nih.gov/pubmed/28874824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11096-1
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