Hyperactive TGF-β Signaling in Smooth Muscle Cells Exposed to HIV-protein(s) and Cocaine: Role in Pulmonary Vasculopathy

We earlier demonstrated synergistic increase in the proliferation of pulmonary smooth muscle cells on exposure to HIV-proteins and/or cocaine due to severe down-modulation of bone morphogenetic protein receptor (BMPR) axis: the anti-proliferative arm of TGF-β super family of receptors. Here, now we...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Dalvi, Pranjali, Sharma, Himanshu, Konstantinova, Tomara, Sanderson, Miles, Brien-Ladner, Amy O’, Dhillon, Navneet K.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585314/
https://ncbi.nlm.nih.gov/pubmed/28874783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10438-3
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