Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas

BACKGROUND: Tumour hypoxia limits the effectiveness of radiation therapy. Delivering normobaric or hyperbaric oxygen therapy elevates pO(2) in both tumour and normal brain tissue. However, pO2 levels return to baseline within 15 minutes of stopping therapy. AIM: To investigate the effect of perfluor...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Feldman, Lisa A., Fabre, Marie-Sophie, Grasso, Carole, Reid, Dana, Broaddus, William C., Lanza, Gregory M., Spiess, Bruce D., Garbow, Joel R., McConnell, Melanie J., Herst, Patries M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584944/
https://ncbi.nlm.nih.gov/pubmed/28873460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184250
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