Ex vivo non-viral gene delivery of μ-opioid receptor (OPRM1) to attenuate cancer-induced pain

Virus-mediated gene delivery shows promise for treatment of chronic pain. However, viral vectors have cytotoxicity. To avoid toxicities and limitations of virus-mediated gene delivery, we developed a novel non-viral hybrid vector: HIV-1 Tat peptide sequence modified with histidine and cysteine resid...

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Vydáno v:Pain
Hlavní autoři: Yamano, Seiichi, Viet, Chi T., Dang, Dongmin, Dai, Jisen, Hanatani, Shigeru, Takayama, Tadahiro, Kasai, Hironori, Imamura, Kentaro, Campbell, Ron, Ye, Yi, Dolan, John C., Kwon, William Myung, Schneider, Stefan D., Schmidt, Brian L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584564/
https://ncbi.nlm.nih.gov/pubmed/28092646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000750
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