Ex vivo non-viral gene delivery of μ-opioid receptor (OPRM1) to attenuate cancer-induced pain

Virus-mediated gene delivery shows promise for treatment of chronic pain. However, viral vectors have cytotoxicity. To avoid toxicities and limitations of virus-mediated gene delivery, we developed a novel non-viral hybrid vector: HIV-1 Tat peptide sequence modified with histidine and cysteine resid...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Yamano, Seiichi, Viet, Chi T., Dang, Dongmin, Dai, Jisen, Hanatani, Shigeru, Takayama, Tadahiro, Kasai, Hironori, Imamura, Kentaro, Campbell, Ron, Ye, Yi, Dolan, John C., Kwon, William Myung, Schneider, Stefan D., Schmidt, Brian L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584564/
https://ncbi.nlm.nih.gov/pubmed/28092646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000750
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