Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase

FAU, a pyrimidine nucleotide analog, is a prodrug bioactivated by intracellular thymidylate synthase to form FMAU that is incorporated into DNA causing cell death. This study presents a model-based approach to integrating dynamic positron emission tomography (PET) and conventional plasma pharmacokin...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Li, Jing, Kim, Seongho, Shields, Anthony F., Douglas, Kirk A., McHugh, Christopher I., Lawhorn-Crews, Jawana M., Wu, Jianmei, Mangner, Thomas J., LoRusso, Patricia M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584379/
https://ncbi.nlm.nih.gov/pubmed/27095537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.751
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