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Tracking cellular stress with labeled FMAU reflects changes in mitochondrial TK2
PURPOSE: Fluoropyrimidines like 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-thymine (FMAU) and 3′-deoxy-3′-fluorothymidine (FLT) accumulate in tumors and are being used as positron emission tomography tumor-imaging tracers. Proliferating tissues with high thymidine kinase 1 (TK1) activity retain FLT...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3826914/ https://ncbi.nlm.nih.gov/pubmed/18265975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-008-0738-9 |
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