G-CSF inhibits LFA-1-mediated CD4(+) T cell functions by inhibiting Lck and ZAP-70

In this study, we showed that G-CSF mobilization increased the frequency of T cells, specifically CD3(+)CD4(+) T cells. G-CSF mobilization decreased the secretion of inflammatory cytokines of CD4(+) T cells through the LFA-1/ICAM-1 signaling pathway, whereas it did not alter the TH1/TH2 ratio. We fo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhao, Shasha, Gu, Zhenyang, Wang, Li, Guan, Lixun, Wang, Feiyan, Yang, Nan, Luo, Lan, Gao, Zhe, Song, Yingwei, Wang, Lili, Liu, Daihong, Gao, Chunji
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584271/
https://ncbi.nlm.nih.gov/pubmed/28881670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18194
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