Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells

T cell–dependent germinal center (GC) responses require coordinated interactions of T cells with two antigen-presenting cell (APC) populations, B cells and dendritic cells (DCs), in the presence of B7- and CD40-dependent co-stimulatory pathways. Contrary to the prevailing paradigm, we found unique c...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Watanabe, Masashi, Fujihara, Chiharu, Radtke, Andrea J., Chiang, Y. Jeffrey, Bhatia, Sumeena, Germain, Ronald N., Hodes, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584122/
https://ncbi.nlm.nih.gov/pubmed/28768709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161955
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