Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

Drug delivery to the brain is hampered by the presence of the blood-brain barrier, which excludes most molecules from freely diffusing into the brain, and tightly regulates the active transport mechanisms that ensure sufficient delivery of nutrients to the brain parenchyma. Harnessing the possibilit...

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Pubblicato in:Sci Rep
Autori principali: Johnsen, Kasper Bendix, Burkhart, Annette, Melander, Fredrik, Kempen, Paul Joseph, Vejlebo, Jonas Bruun, Siupka, Piotr, Nielsen, Morten Schallburg, Andresen, Thomas Lars, Moos, Torben
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583399/
https://ncbi.nlm.nih.gov/pubmed/28871203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11220-1
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