Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery

Pigment epithelium derived factor (PEDF) is a potent antiangiogenic, neurotrophic, and neuroprotective molecule that is the endogenous inhibitor of vascular endothelial growth factor (VEGF) in the retina. An ex vivo gene therapy approach based on transgenic overexpression of PEDF in the eye is assum...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Garcia-Garcia, Laura, Recalde, Sergio, Hernandez, Maria, Bezunartea, Jaione, Rodriguez-Madoz, Juan Roberto, Johnen, Sandra, Diarra, Sabine, Marie, Corinne, Izsvák, Zsuzsanna, Ivics, Zoltán, Scherman, Daniel, Kropp, Martina, Thumann, Gabriele, Prosper, Felipe, Fernandez-Robredo, Patricia, Garcia-Layana, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583395/
https://ncbi.nlm.nih.gov/pubmed/29246287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.08.001
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