The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B

Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin inhibited the deposition of C3b, Bb, Properdin, C5b,...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Mendes-Sousa, Antonio F., do Vale, Vladimir Fazito, Silva, Naylene C. S., Guimaraes-Costa, Anderson B., Pereira, Marcos H., Sant’Anna, Mauricio R. V., Oliveira, Fabiano, Kamhawi, Shaden, Ribeiro, José M. C., Andersen, John F., Valenzuela, Jesus G., Araujo, Ricardo N.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583147/
https://ncbi.nlm.nih.gov/pubmed/28912782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01065
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