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The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways
A genome-wide association study (GWAS) reported that common variation in the human Niemann-Pick C1 gene (NPC1) is associated with morbid adult obesity. This study was confirmed using our BALB/cJ Npc1 mouse model, whereby heterozygous mice (Npc1(+/−)) with decreased gene dosage were susceptible to we...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Am J Physiol Endocrinol Metab |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Physiological Society
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5582887/ https://ncbi.nlm.nih.gov/pubmed/28487438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00369.2016 |
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