The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways

A genome-wide association study (GWAS) reported that common variation in the human Niemann-Pick C1 gene (NPC1) is associated with morbid adult obesity. This study was confirmed using our BALB/cJ Npc1 mouse model, whereby heterozygous mice (Npc1(+/−)) with decreased gene dosage were susceptible to we...

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Publicado en:Am J Physiol Endocrinol Metab
Autores principales: Castillo, Joseph J., Jelinek, David, Wei, Hao, Gannon, Nicholas P., Vaughan, Roger A., Horwood, L. John, Meaney, F. John, Garcia-Smith, Randi, Trujillo, Kristina A., Heidenreich, Randall A., Meyre, David, Orlando, Robert A., LeBoeuf, Renee C., Garver, William S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582887/
https://ncbi.nlm.nih.gov/pubmed/28487438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00369.2016
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