Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB

Menin is a scaffold protein that interacts with several epigenetic mediators to regulate gene transcription, and suppresses pancreatic β-cell proliferation. Tamoxifen-inducible deletion of multiple endocrine neoplasia type 1 (MEN1) gene, which encodes the protein menin, increases β-cell mass in mult...

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Udgivet i:Am J Physiol Endocrinol Metab
Main Authors: Muhammad, Abdul Bari, Xing, Bowen, Liu, Chengyang, Naji, Ali, Ma, Xiaosong, Simmons, Rebecca A., Hua, Xianxin
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582886/
https://ncbi.nlm.nih.gov/pubmed/28270438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00241.2016
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