FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats

Serotonin (5-HT), predominantly synthesized and released by enterochromaffin cells, is implicated in gastrointestinal symptoms such as emesis, abdominal pain, and diarrhea. Because luminal short-chain fatty acids (SCFAs) release 5-HT from enterochromaffin cells, which express the SCFA receptor free...

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Detalles Bibliográficos
Publicado en:Am J Physiol Gastrointest Liver Physiol
Autores principales: Akiba, Yasutada, Maruta, Koji, Narimatsu, Kazuyuki, Said, Hyder, Kaji, Izumi, Kuri, Ayaka, Iwamoto, Ken-ichi, Kuwahara, Atsukazu, Kaunitz, Jonathan D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582879/
https://ncbi.nlm.nih.gov/pubmed/28526687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00041.2017
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