Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats

Dopamine decreases Na-K-ATPase (NKA) activity by PKC-dependent phosphorylation and endocytosis of the NKA α1. Dopamine-mediated regulation of NKA is impaired in aging and some forms of hypertension. Using opossum (OK) proximal tubule cells (PTCs), we demonstrated that sodium-hydrogen exchanger regul...

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Publicat a:Am J Physiol Cell Physiol
Autors principals: Barati, Michelle T., Ketchem, Corey J., Merchant, Michael L., Kusiak, Walter B., Jose, Pedro A., Weinman, Edward J., LeBlanc, Amanda J., Lederer, Eleanor D., Khundmiri, Syed J.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582877/
https://ncbi.nlm.nih.gov/pubmed/28515088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00219.2016
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