Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells

Recent investigations demonstrate increased Na/H exchanger-1 (NHE-1) activity and plasma levels of ouabain-like factor in spontaneously hypertensive rats. At nanomolar concentrations, ouabain increases Na-K-ATPase activity, induces cell proliferation, and activates complex signaling cascades. We hyp...

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Detalhes bibliográficos
Principais autores: Holthouser, Kristine A., Mandal, Amritlal, Merchant, Michael L., Schelling, Jeffrey R., Delamere, Nicholas A., Valdes, Ronald R., Tyagi, Suresh C., Lederer, Eleanor D., Khundmiri, Syed J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904182/
https://ncbi.nlm.nih.gov/pubmed/20427472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00581.2009
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