Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells

The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine protease inhibitor cystatin C is internalized by some cancer cells, which affects cellular properties. Here we aimed to investigate if uptake of cystatin C and the related inhibitor cystatin E/M occur in melanoma...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Wallin, Hanna, Apelqvist, Jenny, Andersson, Freddi, Ekström, Ulf, Abrahamson, Magnus
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582836/
https://ncbi.nlm.nih.gov/pubmed/28630039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.776138
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