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Cystatin C Properties Crucial for Uptake and Inhibition of Intracellular Target Enzymes
To elucidate the molecular requirements for cancer cell internalization of the extracellular cysteine protease inhibitor cystatin C, 12 variants of the protein were produced and used for uptake experiments in MCF-7 cells. Variants with alterations in the cysteine cathepsin binding region ((Δ1–10)-,...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675633/ https://ncbi.nlm.nih.gov/pubmed/23629651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453449 |
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