تحميل...
Paralog-divergent Features May Help Reduce Off-target Effects of Drugs: Hints from Glucagon Subfamily Analysis
Side effects from targeted drugs remain a serious concern. One reason is the nonselective binding of a drug to unintended proteins such as its paralogs, which are highly homologous in sequences and have similar structures and drug-binding pockets. To identify targetable differences between paralogs,...
محفوظ في:
| الحاوية / القاعدة: | Genomics Proteomics Bioinformatics |
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| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Elsevier
2017
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5582795/ https://ncbi.nlm.nih.gov/pubmed/28642113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gpb.2017.03.004 |
| الوسوم: |
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