Paralog-divergent Features May Help Reduce Off-target Effects of Drugs: Hints from Glucagon Subfamily Analysis

Side effects from targeted drugs remain a serious concern. One reason is the nonselective binding of a drug to unintended proteins such as its paralogs, which are highly homologous in sequences and have similar structures and drug-binding pockets. To identify targetable differences between paralogs,...

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Bibliographic Details
Published in:Genomics Proteomics Bioinformatics
Main Authors: Sa, Zhining, Zhou, Jingqi, Zou, Yangyun, Su, Zhixi, Gu, Xun
Format: Artigo
Language:Inglês
Published: Elsevier 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582795/
https://ncbi.nlm.nih.gov/pubmed/28642113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gpb.2017.03.004
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